Polynucleotide Therapy
Skin that heals from within
REJURAN® is a polynucleotide-based treatment that works with your biology to restore the skin's capacity to regenerate.
At House of Ikigai, we offer it as part of a considered, clinician-led approach to skin health.
Our approach
We believe good skin care begins with understanding — your concerns, your skin's history, and what is genuinely likely to help. REJURAN® aligns with that belief. It does not mask or inflate; it supports the skin's own repair processes, quietly and measurably.
The REJURAN® range
Three formulations
REJURAN®Healer
Comprehensive skin rejuvenation
Designed for full-face skin quality improvement texture, elasticity, radiance. Suitable for the cheeks, forehead, temples, perioral region, neck and décolletage. This is the treatment we often begin with when someone is looking to improve overall skin health rather than address a single concern.
CompositionPN (Polynucleotides)
REJURAN®i
Targeted under-eye rejuvenation
Formulated specifically for the periorbital area — the under-eye region, crow's feet and upper eyelid crease. It addresses fine lines and crepiness in one of the most delicate areas of the face, where the skin is thinnest and often the first to show the effects of time.
CompositionPN (Polynucleotides)
REJURAN®S
Scars & localised skin damage
The highest-viscosity formulation in the range, used for atrophic and depressed scarring on the cheeks, temples and jawline. It provides localised lifting and collagen remodelling, making it particularly well suited to acne scarring and other indented skin changes that have not responded well to surface-level treatments.
CompositionPN (Polynucleotides)
Treatment Length: 60 mins
Results seen: 2–4 weeks
Duration of results: Up to 6–12 months
Session frequency: 3 sessions spaced approximately 1 month apart. Multiple sessions may be recommended for best results, tailored to the individual's skin condition and concerns.
The science behind it
How REJURAN®
works
Polynucleotides are long-chain nucleic acid molecules derived from highly purified, biocompatible salmon DNA. When introduced into the dermis, they promote fibroblast activation — the cells responsible for producing collagen, elastin and the structural components that give skin its resilience.
REJURAN® uses proprietary DOT™ technology (DNA Optimisation Technology) to deliver stabilised PN fragments that are optimised for cellular compatibility and maximise dermal repair activity. The result is a gradual, measurable improvement in skin quality — not a surface effect, but a biological one.
This is not volume replacement. This is tissue repair.
Fibroblast activation
PNs stimulate fibroblasts to produce new collagen and elastin, restoring the dermal scaffold that thins with age and environmental stress.
Extracellular matrix support
REJURAN® supports restoration of the extracellular matrix — the structural framework between skin cells — improving overall tissue integrity.
High biocompatibility
Salmon-derived PNs share a high degree of similarity with human DNA, meaning the body accepts and integrates the treatment with minimal inflammatory response.
Gradual, lasting change
Results develop over weeks as new tissue forms. Improvements in texture, tone and skin quality accumulate with each session and persist beyond the treatment period.
Your Questions, Answered
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REJURAN® is a skin regeneration treatment originally developed in South Korea and now used widely across the world. It is an injectable gel made from polynucleotides (PN) — highly purified DNA fragments derived from wild salmon. These fragments are biocompatible, meaning they work naturally and safely with human skin. Rather than filling or freezing anything, REJURAN® works at a cellular level, encouraging your skin to repair and renew itself from within. Think of it as giving your skin the building blocks it needs to do its own best work.
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Once gently injected into the skin, polynucleotides act like a repair signal. They attract and retain moisture deep within the tissue, creating an ideal environment for your skin cells to regenerate. They also support your fibroblasts — the specialist cells responsible for producing collagen and elastin — helping the skin become smoother, firmer, and healthier over time. It is not a quick fix or a surface-level treatment. It is a process of genuine biological renewal, which is precisely why we think it aligns so beautifully with our philosophy here at House of Ikigai..
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The most common starting protocol is a course of three sessions, spaced approximately four weeks apart. That said, your clinician will always tailor this to you — your skin condition, your goals, and what your skin tells us during your consultation. Some people find two sessions sufficient; others benefit from a fourth. We will never recommend more than you need, and we will never suggest less than what will genuinely serve you.
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Results typically last between six and twelve months, depending on your skin's condition, your age, your lifestyle, and how your skin responds over time. Most clients choose to have a review and adjust session at around six to twelve months to maintain what they have achieved. We will always discuss this openly with you rather than simply booking you in — your results and your confidence are what guide us.
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Downtime is generally minimal. Immediately after treatment, you may notice some small injection points, mild redness, or a little swelling — particularly around the treatment area. These typically settle within twenty-four to forty-eight hours. Most clients return to their normal day quite comfortably. We will always talk you through what to expect before we begin, so there are no surprises.
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Most people begin to notice an improvement in their skin's texture and radiance within two to four weeks of their first session. The results are progressive — they build beautifully across your course of treatment rather than appearing all at once. By the end of your course, the difference in how your skin feels and how it behaves tends to be the most meaningful shift. This is not about instant transformation; it is about your skin becoming genuinely better over time.
