Polynucleotide Therapy · 2026
Skin that heals from within
REJURAN® is a polynucleotide-based treatment that works with your biology to restore the skin's capacity to regenerate.
At House of Ikigai, we offer it as part of a considered, clinician-led approach to skin health.
Our approach
We believe good skin care begins with understanding — your concerns, your skin's history, and what is genuinely likely to help. REJURAN® aligns with that belief. It does not mask or inflate; it supports the skin's own repair processes, quietly and measurably.
The REJURAN® range
Three formulations
REJURAN®Healer
Comprehensive skin rejuvenation
Designed for full-face skin quality improvement texture, elasticity, radiance. Suitable for the cheeks, forehead, temples, perioral region, neck and décolletage. This is the treatment we often begin with when someone is looking to improve overall skin health rather than address a single concern.
CompositionPN (Polynucleotides)
REJURAN®i
Targeted under-eye rejuvenation
Formulated specifically for the periorbital area — the under-eye region, crow's feet and upper eyelid crease. It addresses fine lines and crepiness in one of the most delicate areas of the face, where the skin is thinnest and often the first to show the effects of time.
CompositionPN (Polynucleotides)
REJURAN®S
Scars & localised skin damage
The highest-viscosity formulation in the range, used for atrophic and depressed scarring on the cheeks, temples and jawline. It provides localised lifting and collagen remodelling, making it particularly well suited to acne scarring and other indented skin changes that have not responded well to surface-level treatments.
CompositionPN (Polynucleotides)
The science behind it
How REJURAN®
works
Polynucleotides are long-chain nucleic acid molecules derived from highly purified, biocompatible salmon DNA. When introduced into the dermis, they promote fibroblast activation — the cells responsible for producing collagen, elastin and the structural components that give skin its resilience.
REJURAN® uses proprietary DOT™ technology (DNA Optimisation Technology) to deliver stabilised PN fragments that are optimised for cellular compatibility and maximise dermal repair activity. The result is a gradual, measurable improvement in skin quality — not a surface effect, but a biological one.
This is not volume replacement. This is tissue repair.
Fibroblast activation
PNs stimulate fibroblasts to produce new collagen and elastin, restoring the dermal scaffold that thins with age and environmental stress.
Extracellular matrix support
REJURAN® supports restoration of the extracellular matrix — the structural framework between skin cells — improving overall tissue integrity.
High biocompatibility
Salmon-derived PNs share a high degree of similarity with human DNA, meaning the body accepts and integrates the treatment with minimal inflammatory response.
Gradual, lasting change
Results develop over weeks as new tissue forms. Improvements in texture, tone and skin quality accumulate with each session and persist beyond the treatment period.