A Different Kind of Weight Loss Journey

Caring for You After Each Dose

After-Care Guidance: Mounjaro · Wegovy · Rybelsus

What to Expect

The First Few Days

The days following your first dose are the most likely to feel unfamiliar. This is entirely expected. Your body is beginning to respond to a medication that fundamentally alters how your appetite signals work. Most clients find early symptoms ease significantly within two to three weeks with good hydration and nutrition.

You may notice some or all of the following — these are not signs that something has gone wrong:

• Nausea — most common, particularly with Mounjaro and Wegovy

• Reduced appetite or an earlier sense of fullness

• Mild fatigue

• Loose stools or constipation — both are possible in the first week

• Mild injection site redness or tenderness (Mounjaro and Wegovy)

• Mild stomach discomfort (Rybelsus), particularly if taken without water or too close to food

Nutrition

What to Eat, and How

EAT THESE

• Lean proteins at every meal — eggs, fish, chicken, legumes, Greek yoghurt

• Fibre-rich vegetables and whole foods

• Small, frequent meals rather than large ones

• Plain water — 2 to 2.5 litres daily

• Ginger tea if nausea is present

• Soft, low-fat options in the very early days if needed

Medication Handling

Guidance by Medication

Mounjaro (tirzepatide) — Weekly Injection

• Inject subcutaneously — abdomen, upper thigh, or upper arm. Rotate sites weekly.

• Store unused pens in the refrigerator (2–8°C). Do not freeze.

• Once in use, the pen may be kept at room temperature (below 30°C) for up to 21 days.

• Inject on the same day each week, at any time of day, with or without food.

• Do not inject into skin that is bruised, tender, or scarred.

Wegovy (semaglutide) — Weekly Injection

• Inject subcutaneously — abdomen, upper thigh, or upper arm.

• Store in refrigerator (2–8°C). Do not freeze. May be stored at room temperature below 30°C for up to 28 days after first use.

• Administer on the same day each week, with or without food.

• Follow your titration schedule precisely — dose increases are structured to minimise side effects.

Rybelsus (semaglutide oral) — Daily Tablet

• Take on an empty stomach, first thing in the morning.

• Swallow whole with no more than 120ml of plain water only — not coffee, juice, or other liquids.

• Wait at least 30 minutes before eating, drinking anything other than water, or taking other oral medications.

• If you miss a dose, skip it — do not double up the following day.

Managing Side Effects

Common Experiences

Nausea

The most commonly reported experience, particularly in weeks one to four. The single most effective mitigation is hydration. Small sips of water, ginger tea, and avoiding lying down immediately after eating all help. If nausea is severe or persistent beyond three weeks, contact us — your dose timing or titration schedule may need review.

Constipation

Increase fibre intake (vegetables, oats, ground flaxseed), maintain hydration, and move your body daily. Speak to us if symptoms persist beyond two weeks.

Fatigue

Common in the early phase. Ensure your caloric intake remains adequate — undernourishing your body is counterproductive and will deepen fatigue.

Injection Site Reactions

Mild redness or tenderness is expected and typically resolves within 24 to 48 hours. Rotating injection sites each week significantly reduces this.

Your Monitoring Schedule

You Are Never Left Without Support

• Week 2— Initial check-in following your first dose

• Week 4— Review of tolerance and early progress

• Week 8— Dose titration review with your prescriber

• Monthly thereafter— Ongoing monitoring and programme optimisation